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The primary site of action of cocaine is the dopamine uptake transporter DAT; Ritz et al. Activation of either the ionotropic or mGlu receptors results in stimulation of a number of intracellular signaling pathways, ultimately leading to neuronal plasticity.

Free sample sex video video

The rewarding effects of drugs of abuse can also be studied using the CPP procedure for review see Tzschentke, Administration of drugs of abuse lower the reward threshold required to maintain ICSS behavior e. Operant drug self-administration is commonly used to assess the reinforcing effects of nicotine, cocaine, alcohol, and heroin, while non-operant self-administration is used to assess the reinforcing effects of alcohol.

Free sample sex video video

Free sample sex video video

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