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An immunity to the virus is built over time. Some individuals' outbreaks can be quite debilitating, with large, painful lesions persisting for several weeks, while others experience only minor itching or burning for a few days. The original use was against normally fatal or debilitating illnesses such as adult encephalitis,  keratitis,  in immunocompromised transplant patients,  or disseminated herpes zoster.
Antiviral medication has been proven to shorten the frequency and duration of outbreaks. Other identified triggers include local injury to the face, lips, eyes, or mouth; trauma; surgery; radiotherapy ; and exposure to wind, ultraviolet light , or sunlight.
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