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Any significant shifts in pH below about 7 or over 7. However, even in the stomach, the layer just outside the epithelium is quite basic to prevent mucosal injury natural protection mechanism! Excluding chronic renal failure, regardless of what you eat a steak or a green smoothie or what your urine pH is, you can rest assured that your blood pH is hovering around a comfortable 7.
Enzymes that facilitate chemical reactions in the cells work only in a narrow range of pH. I find that pretty amazing.
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